UBE2C

Across TCGA patient cohorts, UBE2C mutation is significantly associated with the RNA expression of many other genes, with 763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2C-associated genes across cancer lineages are RNY4P28, TNKS1BP1, and KCTD14. Each is linked with UBE2C in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2C-to-partner and partner-to-UBE2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P28 grouped by UBE2C-low versus UBE2C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2C→partner) and Y-score (partner→UBE2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNY4P28 →	+0.597	+7.816	<.001	.008	3	2
UCEC	TNKS1BP1 →	+0.426	+3.475	.008	.002	3	1
UCEC	KCTD14 →	+0.945	+3.119	.001	<.001	3	1
UCEC	AP1S3 →	+0.559	+3.483	.002	.002	3	1
UCEC	SAR1B →	+0.514	+3.087	<.001	<.001	3	1
UCEC	PTPRN2 →	+0.508	+4.169	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 763 associations by consensus.

RNY4P28 by UBE2C expression — SKCM

Explore this box plot interactively →