UBE2C

Across TCGA pan-cancer cohorts, UBE2C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated UBE2C data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UBE2C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBE2C expression acts as an unfavorable survival marker, although some lineages such as GBM and THYM show a favorable association.

ACC, KIRP, and MESO are the cancer types where UBE2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.349	0.839	<.001	159	view →
KIRP	DFS	Median	All	0.760	0.940	<.001	157	view →
MESO	OS	Median	All	0.381	0.698	<.001	141	view →
KIRC	DFS	Median	All	0.523	0.737	<.001	136	view →
LIHC	DFS	Tertile	All	0.407	0.655	<.001	110	view →
KICH	DFS	Median	III,IV	0.355	1.000	.001	97	view →
UVM	DFS	Median	All	0.411	0.724	<.001	78	view →
PAAD	OS	Quartile	All	0.249	0.547	<.001	64	view →
LGG	OS	Median	All	0.718	0.907	<.001	54	view →
BRCA	OS	Tertile	III,IV	0.770	0.922	.001	47	view →
THCA	DFS	Median	All	0.764	0.886	.006	37	view →
SKCM	OS	Median	II,III,IV	0.286	0.445	.003	36	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

UBE2C–ACC (OS)

Open the ACC breakdown →