UBE2C

Across TCGA patient cohorts, UBE2C mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2C-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Fibronectin. Each is linked with UBE2C in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2C-to-partner and partner-to-UBE2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by UBE2C-low versus UBE2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2C→partner) and Y-score (partner→UBE2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-2.301	.016	.034	3	1
UCEC	ERK2 →	+0.182	+2.000	.026	.030	3	1
UCEC	Fibronectin →	-0.402	-2.690	.004	.006	3	1
UCEC	MEK1 →	+0.349	+2.222	.024	.011	3	1
UCEC	MSH2 →	-0.346	-3.433	<.001	.005	3	1
UCEC	MSH6 →	-0.462	-1.700	<.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by UBE2C expression — UCEC

Explore this box plot interactively →