Across TCGA pan-cancer cohorts, UBBP2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of UBBP2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where UBBP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBBP2 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

BRCA, KIRC, and THCA are the cancer types where UBBP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBBP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.267	<.001	6	view →
KIRC	All	All	+0.296	<.001	5	view →
THCA	All	All	−0.226	.005	5	view →
LUSC	Female	All	−0.376	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: UBBP2 RNA expression & survival · all UBBP2 data types