UBASH3B

Across TCGA pan-cancer cohorts, UBASH3B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBASH3B data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UBASH3B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBASH3B expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and GBM are the cancer types where UBASH3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.934	0.250	.024	9	view →
LSCC	DFS	Median	All	0.893	0.700	.022	3	view →
GBM	OS	Median	All	0.297	0.493	.048	2	view →
LUAD	OS	Median	III,IV	0.336	0.778	.017	2	view →
CCRCC	DFS	Quartile	All	0.591	1.000	.025	2	view →
HNSC	OS	Quartile	IV	0.942	0.711	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBASH3B–PDAC (DFS)

Open the PDAC breakdown →