UBASH3A

Across TCGA pan-cancer cohorts, UBASH3A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBASH3A data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher UBASH3A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBASH3A expression acts as an unfavorable survival marker.

MESO, SKCM, and UCEC are the cancer types where UBASH3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	IV	0.158	0.473	.011	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBASH3A–MESO (DFS)

Open the MESO breakdown →