UBASH3A

Across TCGA pan-cancer cohorts, UBASH3A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UBASH3A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UBASH3A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBASH3A is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and STAD are the cancer types where UBASH3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBASH3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.375	<.001	11	view →
COAD	All	All	−0.373	.003	8	view →
STAD	All	II,III,IV	+0.854	.006	6	view →
LUSC	All	All	−0.471	.003	5	view →
THCA	All	All	−0.489	.008	4	view →
BLCA	Female	All	−0.857	.046	2	view →
UCEC	All	All	−0.453	.003	2	view →
CHOL	All	All	+0.720	.047	1	view →
KIRP	All	All	+0.345	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UBASH3A–KIRC

Open the KIRC breakdown →