UBASH3A

Across TCGA pan-cancer cohorts, UBASH3A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UBASH3A data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UBASH3A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBASH3A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where UBASH3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.277	0.808	.003	23	view →
HNSC	OS	Median	II,III,IV	0.820	0.965	.044	3	view →
LSCC	DFS	Quartile	All	1.000	0.410	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UBASH3A–LUAD (OS)

Open the LUAD breakdown →