UBASH3A

Across TCGA patient cohorts, UBASH3A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBASH3A-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and Caspase-8. Each is linked with UBASH3A in more than 2 cancer types. Because this analysis shows association rather than direction, both UBASH3A-to-partner and partner-to-UBASH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UBASH3A-low versus UBASH3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBASH3A→partner) and Y-score (partner→UBASH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.183	+2.000	.018	.009	3	3
UCEC	14-3-3_beta →	-0.131	-3.979	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.202	-2.415	.028	.003	3	2
UCEC	CD31 →	-0.108	-1.502	.046	.030	3	2
UCEC	Di-Ras3 →	-0.208	-3.807	<.001	<.001	3	2
COAD	ASNS →	+0.646	+3.008	.001	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by UBASH3A expression — UCEC

Explore this box plot interactively →