UBASH3A

Across TCGA cell cohorts, UBASH3A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBASH3A-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Positive regulation of T cell activation, and Negative regulation of extrinsic apoptotic signaling pathway. Each is linked with UBASH3A in more than 4 cancer types. Because this analysis shows association rather than direction, both UBASH3A-to-partner and partner-to-UBASH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by UBASH3A-low versus UBASH3A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBASH3A→partner) and Y-score (partner→UBASH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.069	+0.039	.001	.003	3	4
STOMACH	Positive regulation of T cell activation →	+0.055	+0.032	.001	.007	2	5
BLOOD_Lymphoma	Negative regulation of extrinsic apoptotic signaling pathway →	+0.071	+1.006	<.001	.001	3	4
PANCREAS	Response to type II interferon →	+0.118	+0.063	<.001	.003	3	4
BLOOD_Leukemia	Positive regulation of autophagy →	+0.023	+1.394	<.001	<.001	3	4
BLOOD_Leukemia	Regulation of protein modification by small protein conjugation or removal →	+0.029	+1.462	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,287 associations by consensus.

Negative regulation of RNA splicing by UBASH3A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →