UBASH3A

Across TCGA cell cohorts, UBASH3A mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible UBASH3A-associated genes across cancer lineages are GAGE12E, SERPINA12, and CCDC63. Each is linked with UBASH3A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBASH3A-to-partner and partner-to-UBASH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12E grouped by UBASH3A-low versus UBASH3A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBASH3A→partner) and Y-score (partner→UBASH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
SKIN	SERPINA12 →	+0.028	+3.920	<.001	.005	3	1
SKIN	CCDC63 →	+0.023	+4.169	<.001	.007	3	1
SKIN	FAM187B →	+0.063	+3.684	<.001	.006	3	1
SKIN	CRYGB →	+0.039	+3.684	<.001	.006	3	1
SKIN	ZNF735 →	+0.012	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GAGE12E by UBASH3A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →