UBAC2

Across TCGA pan-cancer cohorts, UBAC2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated UBAC2 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher UBAC2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBAC2 expression acts as an unfavorable survival marker, although some lineages such as THYM and KIRC show a favorable association.

UVM, ACC, and HNSC are the cancer types where UBAC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.418	0.776	<.001	117	view →
ACC	DFS	Median	All	0.173	0.647	<.001	86	view →
HNSC	OS	Quartile	II,III,IV	0.163	0.606	<.001	85	view →
PAAD	DFS	Median	All	0.191	0.370	<.001	63	view →
LIHC	OS	Tertile	II,III,IV	0.597	0.820	.002	51	view →
THYM	DFS	Median	All	0.953	0.781	.001	42	view →
KIRC	OS	Median	All	0.707	0.535	.003	39	view →
CESC	DFS	Quartile	All	0.633	0.866	<.001	32	view →
LUSC	OS	Quartile	II,III,IV	0.293	0.573	.005	24	view →
KICH	DFS	Tertile	III,IV	0.355	1.000	.010	14	view →
LUAD	OS	Median	All	0.266	0.443	.005	14	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

UBAC2–UVM (OS)

Open the UVM breakdown →