UBAC2

Across TCGA pan-cancer cohorts, UBAC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBAC2 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBAC2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBAC2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where UBAC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.813	0.976	.001	26	view →
LUAD	DFS	Median	III,IV	0.716	0.294	.007	21	view →
CCRCC	OS	Median	IV	0.314	1.000	.001	20	view →
PDAC	OS	Quartile	All	0.317	0.464	.044	3	view →
HNSC	DFS	Quartile	II,III,IV	0.882	0.575	.015	3	view →
UCEC	DFS	Median	All	0.781	0.925	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBAC2–LSCC (OS)

Open the LSCC breakdown →