UBAC2

Across TCGA pan-cancer cohorts, UBAC2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UBAC2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where UBAC2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UBAC2 is over-expressed in tumor.

CCRCC, COAD, and LUAD are the cancer types where UBAC2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBAC2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.480	<.001	11	view →
COAD	Female	II,III,IV	+0.561	<.001	9	view →
LUAD	Female	All	+0.505	<.001	9	view →
LSCC	Male	III,IV	+0.533	<.001	8	view →
PDAC	All	II,III,IV	+0.352	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UBAC2–CCRCC

Open the CCRCC breakdown →