UBAC1

Across TCGA pan-cancer cohorts, UBAC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBAC1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBAC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBAC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, COAD, and CCRCC are the cancer types where UBAC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.766	0.945	.015	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	DFS	Tertile	All	0.921	0.752	.015	5	view →
LUAD	DFS	Quartile	III,IV	0.325	0.867	.026	3	view →
PDAC	OS	Median	III,IV	0.880	0.607	.019	2	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBAC1–LSCC (OS)

Open the LSCC breakdown →