UBAC1

Across TCGA pan-cancer cohorts, UBAC1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of UBAC1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UBAC1 RNA is repressed in tumor relative to normal tissue. In most cancer types UBAC1 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

THCA, LIHC, and LUSC are the cancer types where UBAC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBAC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.199	<.001	9	view →
LIHC	Female	II,III,IV	+0.991	<.001	8	view →
LUSC	Female	All	+1.042	<.001	6	view →
CHOL	All	All	+1.290	<.001	5	view →
HNSC	Male	III,IV	+0.520	.007	5	view →
ESCA	All	All	+0.803	.007	2	view →
KIRP	All	IV	+0.792	.024	2	view →
STAD	All	II,III,IV	+0.430	.011	2	view →
PRAD	All	All	−0.420	<.001	2	view →
BLCA	All	IV	−0.519	.026	1	view →
COAD	Male	All	−0.263	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

UBAC1–THCA

Open the THCA breakdown →