UBAC1

Across TCGA patient cohorts, UBAC1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBAC1-associated genes across cancer lineages are GAPDH, Bim, and Caspase-7-cleavedD198. Each is linked with UBAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBAC1-to-partner and partner-to-UBAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by UBAC1-low versus UBAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBAC1→partner) and Y-score (partner→UBAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.575	+2.999	.026	.035	3	2
UCEC	Bim →	-0.272	-2.459	.032	.020	3	2
UCEC	Caspase-7-cleavedD198 →	+0.805	+3.189	.004	.010	3	2
UCEC	MSH2 →	-0.433	-2.312	<.001	.034	3	1
UCEC	PDK1 →	+0.120	+2.820	.021	.035	3	1
UCEC	SF2 →	-0.144	-3.159	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GAPDH by UBAC1 expression — UCEC

Explore this box plot interactively →