UBA7

Across TCGA patient cohorts, UBA7 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA7-associated genes across cancer lineages are Cyclin-B1, INPP4B, and PCNA. Each is linked with UBA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBA7-to-partner and partner-to-UBA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by UBA7-low versus UBA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA7→partner) and Y-score (partner→UBA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.737	+2.415	.001	.003	3	3
UCEC	INPP4B →	-0.317	-2.584	.015	.010	3	2
UCEC	PCNA →	+0.277	+2.415	.001	.003	3	2
UCEC	14-3-3_beta →	-0.094	-2.295	.020	.033	3	1
UCEC	EGFR_pY1068 →	-0.254	-1.906	.011	.016	3	1
UCEC	EGFR →	-0.169	-3.169	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-B1 by UBA7 expression — UCEC

Explore this box plot interactively →