UBA6-AS1

Across TCGA pan-cancer cohorts, UBA6-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of UBA6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBA6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBA6-AS1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where UBA6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBA6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.946	<.001	12	view →
THCA	All	II,III,IV	−0.415	<.001	9	view →
LUAD	Male	II,III,IV	+0.620	<.001	8	view →
LIHC	Female	II,III,IV	+0.663	<.001	7	view →
KIRC	All	All	+0.302	<.001	7	view →
LUSC	Female	All	+0.659	<.001	6	view →
KIRP	All	II,III,IV	+0.336	.006	4	view →
BRCA	All	All	+0.265	<.001	4	view →
CHOL	Female	All	+1.370	<.001	3	view →
READ	All	II,III,IV	+0.527	.028	3	view →
COAD	Male	All	+0.246	.024	3	view →
UCEC	All	IV	−0.805	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

UBA6-AS1–HNSC

Open the HNSC breakdown →