UBA5

Across TCGA pan-cancer cohorts, UBA5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBA5 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UBA5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBA5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where UBA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	IV	0.381	0.951	.006	18	view →
CCRCC	DFS	Median	All	0.585	0.879	.001	13	view →
UCEC	OS	Median	III,IV	1.000	0.531	.030	12	view →
LSCC	OS	Tertile	All	0.653	0.885	.023	6	view →
HNSC	DFS	Tertile	III,IV	0.712	0.447	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBA5–PDAC (OS)

Open the PDAC breakdown →