UBA5

Across TCGA pan-cancer cohorts, UBA5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of UBA5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UBA5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBA5 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where UBA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.931	<.001	11	view →
HNSC	Male	IV	+0.816	<.001	11	view →
THCA	Male	All	−0.505	<.001	10	view →
LIHC	Male	All	+0.877	<.001	9	view →
KIRP	Male	All	−0.523	<.001	6	view →
BRCA	All	II,III,IV	+0.220	.003	6	view →
CHOL	All	All	+1.234	<.001	5	view →
LUSC	All	All	+0.530	<.001	5	view →
COAD	Male	II,III,IV	+0.367	<.001	3	view →
READ	All	III,IV	+0.650	.010	2	view →
PRAD	All	All	+0.204	.049	2	view →
LUAD	All	All	+0.178	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

UBA5–KIRC

Open the KIRC breakdown →