UBA5

Across TCGA patient cohorts, UBA5 mutation is significantly associated with the RNA expression of many other genes, with 1,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA5-associated genes across cancer lineages are RNA5SP247, TRAJ57, and MRPS17P5. Each is linked with UBA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA5-to-partner and partner-to-UBA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP247 grouped by UBA5-low versus UBA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA5→partner) and Y-score (partner→UBA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP247 →	+0.450	+1.831	<.001	.005	3	2
COAD	TRAJ57 →	+0.891	+4.542	<.001	.001	3	2
BRCA	MRPS17P5 →	+0.210	+4.841	.005	.006	3	1
BRCA	IGKV2OR2-10 →	+0.279	+4.635	<.001	.004	3	1
BRCA	RNU5A-8P →	+0.649	+4.290	.002	.008	3	1
BRCA	SNORA3C →	+0.333	+4.800	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,505 associations by consensus.

RNA5SP247 by UBA5 expression — UCEC

Explore this box plot interactively →