UBA5

Across TCGA patient cohorts, UBA5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA5-associated genes across cancer lineages are EGFR_pY1068, JNK2, and MAPK_pT202_Y204. Each is linked with UBA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA5-to-partner and partner-to-UBA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBA5-low versus UBA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA5→partner) and Y-score (partner→UBA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.230	-2.459	.031	.019	3	1
UCEC	JNK2 →	+0.240	+2.834	.004	.034	3	1
UCEC	MAPK_pT202_Y204 →	-0.476	-2.321	.016	.034	3	1
UCEC	mTOR_pS2448 →	-0.193	-3.308	.002	.009	3	1
UCEC	p27_pT198 →	+0.135	+2.906	.002	.001	3	1
UCEC	p90 RSK_pT359_S363 →	-0.207	-2.222	.016	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by UBA5 expression — UCEC

Explore this box plot interactively →