UBA2

Across TCGA patient cohorts, UBA2 mutation is significantly associated with the RNA expression of many other genes, with 2,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA2-associated genes across cancer lineages are RPS10-NUDT3, TMEM269, and PIGW. Each is linked with UBA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA2-to-partner and partner-to-UBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10-NUDT3 grouped by UBA2-low versus UBA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA2→partner) and Y-score (partner→UBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS10-NUDT3 →	+0.232	+2.139	<.001	<.001	3	2
UCEC	TMEM269 →	+0.199	+2.617	<.001	<.001	3	2
UCEC	PIGW →	+0.606	+2.595	<.001	<.001	3	2
UCEC	ZNF771 →	+0.368	+1.874	.004	.002	3	2
UCEC	RCC1 →	+0.435	+3.855	.002	<.001	3	2
UCEC	CCDC43 →	+0.511	+3.021	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,578 associations by consensus.

RPS10-NUDT3 by UBA2 expression — UCEC

Explore this box plot interactively →