UACA

Across TCGA patient cohorts, UACA mutation is significantly associated with the RNA expression of many other genes, with 4,075 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UACA-associated genes across cancer lineages are MIS18A, RNU6-176P, and RPS29P9. Each is linked with UACA in more than 3 cancer types. Because this analysis shows association rather than direction, both UACA-to-partner and partner-to-UACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIS18A grouped by UACA-low versus UACA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UACA→partner) and Y-score (partner→UACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIS18A →	+0.347	+1.716	.009	.003	3	4
READ	RNU6-176P →	+0.468	+6.257	<.001	.001	3	3
BLCA	RPS29P9 →	+0.110	+2.565	.001	.008	3	3
LIHC	HMGB1P25 →	+0.064	+6.676	<.001	<.001	3	3
LIHC	EZH2P1 →	+0.117	+5.186	<.001	.007	3	3
UCEC	HAUS1 →	+0.454	+2.413	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,075 associations by consensus.

MIS18A by UACA expression — UCEC

Explore this box plot interactively →