U2SURP

Across TCGA pan-cancer cohorts, U2SURP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated U2SURP data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher U2SURP Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated U2SURP expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, LUSC, and LUAD are the cancer types where U2SURP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.953	0.611	.002	32	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	6	view →
LUAD	OS	Median	II,III,IV	0.141	0.677	.002	6	view →
BLCA	DFS	Median	All	1.000	0.608	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

U2SURP–UCEC (DFS)

Open the UCEC breakdown →