U2SURP

Across TCGA pan-cancer cohorts, U2SURP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated U2SURP data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher U2SURP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated U2SURP expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where U2SURP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.355	1.000	.014	35	view →
PDAC	DFS	Quartile	All	0.307	0.593	.010	18	view →
LUAD	OS	Median	II,III,IV	0.782	0.497	.017	15	view →
CCRCC	DFS	Median	All	0.694	0.911	.003	14	view →
GBM	OS	Tertile	All	0.544	0.228	.001	14	view →
LSCC	DFS	Quartile	II,III,IV	0.883	0.523	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

U2SURP–HNSC (DFS)

Open the HNSC breakdown →