U2SURP

Across TCGA pan-cancer cohorts, U2SURP mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of U2SURP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where U2SURP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types U2SURP is over-expressed in tumor.

HNSC, COAD, and LSCC are the cancer types where U2SURP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in U2SURP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.516	<.001	11	view →
COAD	Male	III,IV	+0.516	<.001	11	view →
LSCC	Male	II,III,IV	+0.652	<.001	9	view →
LUAD	Male	III,IV	+0.407	<.001	9	view →
PDAC	All	II,III,IV	+0.161	<.001	4	view →
OV	All	All	+0.417	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

U2SURP–HNSC

Open the HNSC breakdown →