U2AF2

Across TCGA patient cohorts, U2AF2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,301 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible U2AF2-associated genes across cancer lineages are HELLS, CSE1L, and MGME1. Each is linked with U2AF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both U2AF2-to-partner and partner-to-U2AF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, U2AF2 versus HELLS in LUAD, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF2→partner) and Y-score (partner→U2AF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HELLS →	+0.829	+0.138	<.001	.001	3	7
HNSC	CSE1L →	+0.835	+0.202	<.001	<.001	3	7
HNSC	MGME1 →	+0.835	+0.186	<.001	<.001	3	7
LUAD	DNA2 →	+0.828	+0.147	<.001	.001	3	7
UCEC	CDC25A →	+0.864	+0.151	<.001	.003	3	7
UCEC	NPM1P9 →	+0.874	+0.205	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,301 associations by consensus.

U2AF2 vs HELLS — LUAD

Explore this scatter interactively →