U2AF2

Across TCGA pan-cancer cohorts, U2AF2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated U2AF2 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher U2AF2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated U2AF2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and GBM show a favorable association.

MESO, ACC, and LIHC are the cancer types where U2AF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.406	0.671	<.001	125	view →
ACC	DFS	Median	All	0.409	0.745	<.001	85	view →
LIHC	DFS	Tertile	All	0.436	0.608	<.001	66	view →
SCLC	OS	Quartile	All	0.710	0.311	.001	65	view →
LGG	DFS	Median	All	0.620	0.855	<.001	54	view →
KICH	DFS	Quartile	II,III,IV	0.535	0.962	.008	48	view →
LUAD	DFS	Median	All	0.746	0.865	<.001	47	view →
KIRP	DFS	Median	All	0.369	0.694	.001	40	view →
UVM	OS	Tertile	III,IV	0.318	1.000	.010	35	view →
SARC	OS	Median	All	0.383	0.645	<.001	29	view →
GBM	DFS	Median	All	0.385	0.185	.001	21	view →
LUSC	DFS	Median	III,IV	0.526	0.914	.011	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

U2AF2–MESO (OS)

Open the MESO breakdown →