U2AF2

Across TCGA patient cohorts, U2AF2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible U2AF2-associated genes across cancer lineages are ERK2, AMPK_pT172, and STAT5a. Each is linked with U2AF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both U2AF2-to-partner and partner-to-U2AF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by U2AF2-low versus U2AF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF2→partner) and Y-score (partner→U2AF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.232	+3.169	.016	.018	3	1
UCEC	AMPK_pT172 →	+0.469	+2.999	.023	.035	3	1
UCEC	STAT5a →	+0.423	+2.321	.035	.035	3	1
UCEC	VHL →	-1.169	-3.459	<.001	.005	3	1
UCEC	c-Kit →	-0.275	-3.459	.019	.005	2	1
UCEC	p62 Lck ligand →	+0.378	+2.321	.020	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by U2AF2 expression — UCEC

Explore this box plot interactively →