U2AF2

Across TCGA cell cohorts, U2AF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,632 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible U2AF2-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Nucleosome disassembly, and DNA replication. Each is linked with U2AF2 in more than 17 cancer types. Because this analysis shows association rather than direction, both U2AF2-to-partner and partner-to-U2AF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by U2AF2-low versus U2AF2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF2→partner) and Y-score (partner→U2AF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.109	+0.804	<.001	<.001	3	18
BONE	Nucleosome disassembly →	+0.209	+0.916	<.001	<.001	3	18
BONE	DNA replication →	+0.153	+1.030	<.001	<.001	3	17
BONE	DNA replication checkpoint signaling →	+0.242	+0.990	<.001	<.001	3	17
BONE	DNA strand elongation involved in DNA replication →	+0.218	+0.859	.002	.003	3	17
BONE	Mitotic DNA replication →	+0.243	+1.117	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,632 associations by consensus.

mRNA alternative polyadenylation by U2AF2 expression — LARGE_INTESTINE

Explore this box plot interactively →