U2AF2

Across TCGA cell cohorts, U2AF2 mutation is significantly associated with the mutation status of many other genes, with 2,289 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible U2AF2-associated genes across cancer lineages are FBH1, VPS37A, and FGF18. Each is linked with U2AF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both U2AF2-to-partner and partner-to-U2AF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBH1 grouped by U2AF2-low versus U2AF2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF2→partner) and Y-score (partner→U2AF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBH1 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	VPS37A →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	FGF18 →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	SIX2 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	HS6ST2 →	+4.736	+5.560	.003	.003	1	3
LUNG_NSCLC_LUAD	NCDN →	+4.187	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,289 associations by consensus.

FBH1 by U2AF2 expression — BLOOD_Leukemia

Explore this box plot interactively →