U2AF1

Across TCGA patient cohorts, U2AF1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible U2AF1-associated genes across cancer lineages are RNU6-1286P, ZNF114P1, and MTND4LP16. Each is linked with U2AF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both U2AF1-to-partner and partner-to-U2AF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1286P grouped by U2AF1-low versus U2AF1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF1→partner) and Y-score (partner→U2AF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1286P →	+0.368	+7.640	<.001	.009	3	1
BLCA	ZNF114P1 →	+0.159	+7.640	<.001	.009	3	1
BLCA	MTND4LP16 →	+0.119	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

RNU6-1286P by U2AF1 expression — BLCA

Explore this box plot interactively →