TYSND1

Across TCGA pan-cancer cohorts, TYSND1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TYSND1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TYSND1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TYSND1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, PDAC, and GBM are the cancer types where TYSND1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.457	.021	24	view →
PDAC	DFS	Quartile	II,III,IV	0.459	0.896	.004	23	view →
GBM	DFS	Tertile	All	0.516	0.894	.003	9	view →
OV	DFS	Median	All	0.863	1.000	.034	4	view →
CCRCC	OS	Median	IV	1.000	0.150	.036	4	view →
LUAD	OS	Median	II,III,IV	0.888	0.425	.016	3	view →
LSCC	DFS	Median	III,IV	0.909	0.503	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TYSND1–UCEC (OS)

Open the UCEC breakdown →