TYRO3

Across TCGA pan-cancer cohorts, TYRO3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TYRO3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TYRO3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TYRO3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC and GBM are the cancer types where TYRO3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.987	0.682	.011	6	view →
GBM	DFS	Quartile	All	0.834	0.596	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TYRO3–LSCC (OS)

Open the LSCC breakdown →