TYMS

Across TCGA pan-cancer cohorts, TYMS RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TYMS data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TYMS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TYMS expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

ACC, MESO, and LIHC are the cancer types where TYMS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.202	0.681	<.001	143	view →
MESO	OS	Median	All	0.372	0.699	<.001	123	view →
LIHC	DFS	Median	All	0.454	0.630	<.001	89	view →
KICH	OS	Median	III,IV	0.363	0.957	<.001	86	view →
KIRC	DFS	Tertile	All	0.760	0.418	<.001	71	view →
LGG	OS	Median	All	0.730	0.891	<.001	53	view →
LUAD	OS	Median	All	0.263	0.450	<.001	43	view →
UVM	DFS	Median	All	0.341	0.619	.006	40	view →
PAAD	OS	Tertile	All	0.284	0.530	<.001	32	view →
SKCM	OS	Quartile	II,III,IV	0.220	0.399	.003	30	view →
OV	OS	Tertile	IV	0.629	0.245	<.001	28	view →
SARC	OS	Tertile	All	0.400	0.804	<.001	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TYMS–ACC (DFS)

Open the ACC breakdown →