TYMS

Across TCGA pan-cancer cohorts, TYMS RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TYMS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TYMS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TYMS is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, BLCA, and LUAD are the cancer types where TYMS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYMS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.403	<.001	12	view →
BLCA	All	III,IV	+1.907	<.001	12	view →
LUAD	Male	III,IV	+2.703	<.001	11	view →
KIRP	Female	II,III,IV	+2.106	<.001	11	view →
HNSC	Male	III,IV	+1.581	<.001	11	view →
THCA	Male	III,IV	+1.338	<.001	10	view →
LIHC	Female	III,IV	+2.956	<.001	9	view →
LUSC	Female	All	+2.732	<.001	8	view →
STAD	All	II,III,IV	+1.933	<.001	8	view →
UCEC	All	III,IV	+3.011	<.001	6	view →
BRCA	All	III,IV	+1.711	<.001	6	view →
ESCA	All	All	+2.340	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TYMS–KIRC

Open the KIRC breakdown →