TYMP

Across TCGA patient cohorts, TYMP mutation is significantly associated with the RNA expression of many other genes, with 548 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYMP-associated genes across cancer lineages are OR10G3, OR2M2, and RN7SKP104. Each is linked with TYMP in more than 1 cancer types. Because this analysis shows association rather than direction, both TYMP-to-partner and partner-to-TYMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G3 grouped by TYMP-low versus TYMP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYMP→partner) and Y-score (partner→TYMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR10G3 →	+0.063	+5.788	<.001	.003	3	2
BLCA	OR2M2 →	+0.141	+6.018	<.001	.002	3	2
BLCA	RN7SKP104 →	+0.178	+7.307	<.001	<.001	3	2
BLCA	MTND1P5 →	+0.181	+5.788	<.001	.003	3	2
BLCA	OR9I3P →	+0.092	+5.251	<.001	.006	3	2
BLCA	CYP4F36P →	+1.265	+4.973	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 548 associations by consensus.

OR10G3 by TYMP expression — BLCA

Explore this box plot interactively →