TYMP

Across TCGA pan-cancer cohorts, TYMP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TYMP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TYMP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TYMP is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where TYMP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYMP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.990	<.001	12	view →
HNSC	Male	All	+1.982	<.001	11	view →
KIRP	Male	III,IV	+2.128	<.001	9	view →
BLCA	Male	IV	+3.327	<.001	8	view →
STAD	Female	All	+2.725	<.001	8	view →
LIHC	Female	All	+1.291	<.001	8	view →
BRCA	All	All	+1.294	<.001	6	view →
LUAD	Female	II,III,IV	+0.743	.009	6	view →
COAD	All	II,III,IV	+0.709	<.001	6	view →
CHOL	All	All	+1.785	<.001	3	view →
ESCA	All	All	+2.628	.001	2	view →
PAAD	Male	All	−0.724	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TYMP–KIRC

Open the KIRC breakdown →