TYK2

Across TCGA patient cohorts, TYK2 mutation is significantly associated with the RNA expression of many other genes, with 2,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYK2-associated genes across cancer lineages are GCAT, SF3B6, and ECHS1. Each is linked with TYK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TYK2-to-partner and partner-to-TYK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by TYK2-low versus TYK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYK2→partner) and Y-score (partner→TYK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GCAT →	+0.478	+2.491	.001	.001	3	4
LUSC	SF3B6 →	+0.499	+3.333	.001	.005	3	3
SKCM	ECHS1 →	+0.344	+2.636	.001	.005	3	3
SKCM	MRTO4 →	+0.341	+1.784	.007	.008	2	4
SKCM	HDHD5 →	+0.378	+2.189	.008	.001	3	3
UCEC	DDAH1 →	+0.532	+1.447	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,277 associations by consensus.

GCAT by TYK2 expression — UCEC

Explore this box plot interactively →