TYK2

Across TCGA patient cohorts, TYK2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYK2-associated genes across cancer lineages are MEK1, eEF2, and eIF4E. Each is linked with TYK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TYK2-to-partner and partner-to-TYK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TYK2-low versus TYK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYK2→partner) and Y-score (partner→TYK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.261	+1.678	.020	.019	3	4
UCEC	eEF2 →	+0.276	+1.906	.011	.014	3	3
UCEC	eIF4E →	+0.179	+1.925	.005	.004	3	3
UCEC	EGFR_pY1068 →	-0.251	-2.502	.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.094	-1.064	.010	.048	3	2
UCEC	FOXO3a_pS318_S321 →	-0.086	-1.916	.023	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

MEK1 by TYK2 expression — UCEC

Explore this box plot interactively →