TYK2

Across TCGA cell cohorts, TYK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,485 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TYK2-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, mRNA cis splicing, via spliceosome, and Microtubule nucleation. Each is linked with TYK2 in more than 16 cancer types. Because this analysis shows association rather than direction, both TYK2-to-partner and partner-to-TYK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by TYK2-low versus TYK2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TYK2→partner) and Y-score (partner→TYK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.134	+0.652	<.001	.002	3	17
URINARY_TRACT	mRNA cis splicing, via spliceosome →	+0.115	+1.163	<.001	<.001	3	17
BONE	Microtubule nucleation →	+0.119	+0.636	<.001	<.001	3	15
OESOPHAGUS	mRNA splice site recognition →	+0.159	+0.962	<.001	<.001	3	15
OESOPHAGUS	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.109	+0.831	.001	.005	3	15
UPPER_AERODIGESTIVE_TRACT	Microtubule polymerization →	+0.104	+1.221	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,485 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by TYK2 expression — OESOPHAGUS

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