TXNL4B

Across TCGA pan-cancer cohorts, TXNL4B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TXNL4B data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TXNL4B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TXNL4B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where TXNL4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.993	0.940	.024	6	view →
LSCC	DFS	Median	II,III,IV	0.891	0.650	.005	4	view →
CCRCC	OS	Tertile	All	0.645	1.000	.018	3	view →
LUAD	OS	Median	III,IV	0.226	0.630	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TXNL4B–HNSC (OS)

Open the HNSC breakdown →