TXNL4A

Across TCGA pan-cancer cohorts, TXNL4A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TXNL4A data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TXNL4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TXNL4A expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TXNL4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.810	0.964	.009	26	view →
PDAC	DFS	Median	II,III,IV	0.487	0.246	.002	21	view →
LUAD	DFS	Median	II,III,IV	0.742	0.303	.011	13	view →
CCRCC	DFS	Median	All	0.849	0.981	.001	11	view →
LSCC	OS	Quartile	All	0.962	0.779	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TXNL4A–HNSC (OS)

Open the HNSC breakdown →