TXNL4A

Across TCGA pan-cancer cohorts, TXNL4A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TXNL4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TXNL4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TXNL4A is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

KIRC, LIHC, and STAD are the cancer types where TXNL4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXNL4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.447	<.001	10	view →
LIHC	Male	II,III,IV	+1.200	<.001	9	view →
STAD	Male	II,III,IV	+0.666	<.001	9	view →
BLCA	All	All	+0.432	.001	9	view →
LUAD	Male	All	+0.414	<.001	7	view →
UCEC	All	III,IV	+1.203	<.001	6	view →
BRCA	All	All	+0.451	<.001	6	view →
LUSC	All	All	+0.550	<.001	5	view →
COAD	Female	II,III,IV	+0.465	<.001	4	view →
CHOL	Male	All	+1.308	<.001	3	view →
PRAD	All	All	+0.253	<.001	2	view →
HNSC	Female	All	−0.316	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TXNL4A–KIRC

Open the KIRC breakdown →