TXNL4A

Across TCGA patient cohorts, TXNL4A mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TXNL4A-associated genes across cancer lineages are MIR6821, MBD3L5, and RN7SL91P. Each is linked with TXNL4A in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNL4A-to-partner and partner-to-TXNL4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6821 grouped by TXNL4A-low versus TXNL4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNL4A→partner) and Y-score (partner→TXNL4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6821 →	+0.533	+3.382	.001	.004	3	1
SKCM	MBD3L5 →	+0.062	+7.219	<.001	<.001	3	1
SKCM	RN7SL91P →	+0.151	+5.771	<.001	.003	3	1
SKCM	RN7SL677P →	+0.136	+5.362	.001	.005	3	1
SKCM	AK4P2 →	+0.075	+5.037	<.001	.009	3	1
SKCM	IGLVV-58 →	+0.457	+5.159	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MIR6821 by TXNL4A expression — UCEC

Explore this box plot interactively →