TXNL4A

Across TCGA cell cohorts, TXNL4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,410 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TXNL4A-associated GO terms across cancer lineages are Establishment of meiotic spindle orientation, Negative regulation of mitotic spindle assembly checkpoint signaling, and Negative regulation of spindle checkpoint. Each is linked with TXNL4A in more than 13 cancer types. Because this analysis shows association rather than direction, both TXNL4A-to-partner and partner-to-TXNL4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of meiotic spindle orientation grouped by TXNL4A-low versus TXNL4A-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNL4A→partner) and Y-score (partner→TXNL4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Establishment of meiotic spindle orientation →	+0.149	+0.613	<.001	.001	3	14
SKIN	Negative regulation of mitotic spindle assembly checkpoint signaling →	+0.167	+0.859	<.001	.001	3	12
SKIN	Negative regulation of spindle checkpoint →	+0.167	+0.859	<.001	.001	3	12
BREAST	Defense response to bacterium →	-0.146	-1.194	<.001	<.001	3	11
BREAST	Positive regulation of inflammatory response →	-0.095	-1.072	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Pseudouridine synthesis →	+0.079	+0.899	.005	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,410 associations by consensus.

Establishment of meiotic spindle orientation by TXNL4A expression — CNS

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