TXNL1

Across TCGA patient cohorts, TXNL1 mutation is significantly associated with the RNA expression of many other genes, with 1,904 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNL1-associated genes across cancer lineages are MIR4445, RNU6-694P, and OR4A8. Each is linked with TXNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNL1-to-partner and partner-to-TXNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by TXNL1-low versus TXNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNL1→partner) and Y-score (partner→TXNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4445 →	+0.146	+4.156	<.001	.004	3	2
COAD	RNU6-694P →	+0.523	+5.893	<.001	.002	3	2
COAD	OR4A8 →	+0.109	+8.153	<.001	<.001	3	2
UCEC	LINC01072 →	+0.181	+2.958	<.001	<.001	3	2
LIHC	MIR6827 →	+0.604	+6.149	<.001	.002	3	1
UCEC	CCNQ →	+0.306	+2.763	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,904 associations by consensus.

MIR4445 by TXNL1 expression — UCEC

Explore this box plot interactively →