TXNL1

Across TCGA pan-cancer cohorts, TXNL1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TXNL1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TXNL1 RNA is repressed in tumor relative to normal tissue. In most cancer types TXNL1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, LIHC, and BRCA are the cancer types where TXNL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXNL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.583	<.001	11	view →
LIHC	Male	II,III,IV	+1.001	<.001	8	view →
BRCA	All	All	+0.250	<.001	6	view →
LUSC	Male	All	+0.436	<.001	5	view →
KIRP	Male	All	−0.379	<.001	5	view →
KICH	Female	All	−0.624	.001	4	view →
CHOL	All	All	+1.021	<.001	3	view →
KIRC	All	IV	+0.249	.023	2	view →
BLCA	Male	III,IV	−0.467	.024	1	view →
LUAD	Male	II,III,IV	+0.244	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TXNL1–THCA

Open the THCA breakdown →